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The Health Benefits of Fish Oil Omega-3 Essential Fatty Acids

Research has revealed the importance of fish oil omega-3 essential fatty acids (EPA/DHA). Numerous studies have indicated fish oils play an important role for many aspects of health, including:

CARDIOVASCULAR HEALTH

Studies suggest that fish oil promotes healthy lipid and triglyceride metabolism, blood flow, vascular dilation and tone, platelet function, endothelial function, and erythrocyte membrane composition. Research also suggests the potential for fish oil to contribute to healthy homocysteine metabolism. Furthermore, fish oil may help to protect the cardiovascular system from the effects of occasional stress. In a recent meta-analysis of 11 trials involving over 15,000 subjects, fish oil was associated with providing overall cardiovascular benefit.*

JOINT FUNCTION

Fish oil acts in part by maintaining healthy prostaglandin, cytokine and leukotriene production, supporting connective tissue and cartilage integrity. It also plays a role in moderating neutrophil activity, supporting joint comfort. Numerous small double blind trials indicate that the omega-3 fatty acids in fish oil promote joint motility and joint comfort. Another double blind, placebo–controlled, prospective study revealed that fish oil modulates immune mediator activity as well as provides support for joint flexibility.*

COGNITIVE/EMOTIONAL HEALTH (ADULTS)

Omega-3 fatty acids are important components of neuronal cell membranes and are essential to cognitive function. By supporting vascular health, fish oils promote oxygen and nutrient delivery to the brain. Studies suggest that healthy red blood cell membrane omega-3 fatty acid concentration is associated with emotional well-being. Both epidemiological and double blind placebo-controlled trials indicate that fish oil supports positive mood. Furthermore, dietary intake of omega-3 fatty acids in adults has been associated with maintaining healthy EPA/DHA serum levels as well as a healthy EPA to arachidonic acid ratio, providing potential support for mental function.*

COGNITIVE/VISUAL DEVELOPMENT (CHILDREN)

Fish oil promotes healthy mental function and maturation of the central nervous system, including support for cell health and neurotransmission. Essential fatty acids are also vital constituents of the retina, helping to support healthy visual function. EPA and DHA consumption by breast fed infants and children born to mothers who supplement with fish oils has demonstrated support for visual acuity and cognitive development. A longitudinal study suggests that infants born to mothers with higher DHA status demonstrated healthy cognitive capacity at 12 and 18 months. A randomized double blind study suggested that 4 year olds born to mothers who had taken fish oil had healthy cognitive function. Another study suggested that fish oil supplementation may enhance healthy night vision in children. Several studies have also revealed a relationship between dietary omega-3 fatty acids, healthy brain function and sleep patterns.*

RESPIRATORY FUNCTION

Fish oil has demonstrated the potential to support bronchial smooth muscle function by moderating leukotriene and interleukin production. Double blind randomized studies indicate that fish oil supplementation may promote healthy respiratory function in children and adults. Another randomized controlled trial involving 10 elite athletes suggests that fish oil supplementation encourages healthy post-exercise pulmonary function.*

IMMUNE RESPONSE

Essential fatty acids appear to exert a beneficial effect on the immune response by maintaining healthy cytokine activity at the level of gene expression.*

GASTROINTESTINAL HEALTH

Fish oil supplementation has been associated with a soothing effect for the gastrointestinal (GI) tract. In a double blind, placebo-controlled crossover trial, subjects experienced positive support for GI comfort. A separate 6 month trial revealed that fish oil supplementation maintained healthy leukotriene production and immune cell activity in the colon.*

SKIN HEALTH

Fish oils promote vascular health, supporting oxygen and nutrient delivery to the skin. Studies have shown that omega-3 fatty acids protect keratinocytes and fibroblasts from free radicals and immune mediators generated by sun exposure, helping to soothe the skin. Additionally, they help promote elasticity and hydration for smoother looking skin.*

References

Kris-Etherton P, Harris W, Appel L. Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease. Circulation. 2002;106:2747.
Volker D, Fitzgerald P, Major G, Garg M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol. 2000 Oct;27(10):2343-6.
Kremer JM, Lawrence DA, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs. Clinical and immune correlates. Arthritis Rheum. 1995 Aug;38(8):1107-14.
Sundrarjun T, Komindr S, Archararit N, et al. Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid arthritis. J Int Med Res. 2004 Sep-Oct;32(5):443-54.
Khan F, Elherik K, Bolton-Smith C, Barr R, et al. The effects of dietary fatty acid supple-mentation on endothelial function and vascular tone in healthy subjects. Cardiovasc Res. 2003 Oct 1;59(4):955-62.
Thies F, Garry JM, Yaqoob P, et al. Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial. Lancet. 2003 Feb 8;361(9356):477-85.
Nestel P, Shige H, Pomeroy S, et al. The n-3 fatty acids eicosapentaenoic acid and docosa-hexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr. 2002 Aug;76(2):326-30.
Chan DC, Watts GF, Mori TA, et al. Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am J Clin Nutr. 2003 Feb;77(2):300-7.
von Schacky C, Angerer P, Kothny W, et al. The effect of dietary omega-3 fatty acids on coronary atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1999 Apr ;130(7):554-62.
Miyajima T, Tsujino T, Saito K, Yokoyama M. Effects of eicosapentaenoic acid on blood pressure, cell membrane fatty acids, and intracellular sodium concentration in essential hypertension. Hypertens Res. 2001 Sep;24(5):537-42.
Tagawa T, Hirooka Y, Shimokawa H, et al. Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease. Hypertens Res. 2002;25(6):823-9.
Hamazaki T, Sawazaki S, Itomura M, et al. The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest. 1996 Feb 15;97(4):1129-33.
Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med. 2002 Mar;112(4):298-304.
Grundt H, Nilsen DW, Mansoor MA, Hetland O, Nordoy A. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb. 2003 Mar-12
Young GS, Conquer JA, Thomas R. Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. Reprod Nutr Dev. 2005 Sep-Oct;45(5):549-58.
Stevens LJ, Zentall SS, Abate ML, Kuczek T, Burgess JR. Omega-3 fatty acids in boys with behavior, learning, and health problems. Physiol Behav. 1996 Apr-May;59(4-5):915-20.
Dunstan JA, Mori TA, Barden A, et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol. 2003 Dec;112(6):1178-84.
Mickleborough TD, Murray RL, Ionescu AA, Lindley MR. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med. 2003 Nov;168(10):1181-9.
Dry J, Vincent D. Effect of a fish oil diet on asthma: results of a 1-year double-blind study. Int Arch Allergy Appl Immunol. 1991;95(2-3):156-7.
Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. Eur Respir J. 2000 Nov;16(5):861-5.
Colombo J, Kannass KN, Shaddy DJ, et al. Maternal DHA and the development of attention in infancy and toddlerhood. Child Dev. 2004 Jul-Aug;75(4):1254-67.
Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003 Jan;111(1):e39-44.
Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE. Essential fatty acids in visual and brain development. Lipids. 2001 Sep;36(9):885-95.
Wallace FA, Miles EA, Evans C, et al. Dietary fatty acids influence the production of Th1-but not Th2-type cytokines. J Leukoc Biol. 2001 Mar;69(3):449-57.
Rangi SP, Serwonska MH, Lenahan GA, et al. Suppression by ingested eicosapentaenoic acid of the increases in nasal mucosal blood flow and eosinophilia of ryegrass-allergic reactions. J Allergy Clin Immunol. 1990 Feb;85(2):484-9.
Aslan A, Triadafilopoulos G. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol. 1992 Apr;87(4):432-7.
Almallah YZ, El-Tahir A, Heys SD, Richardson S, Eremin O. Distal procto-colitis and n-3 polyunsaturated fatty acids: the mechanism(s) of natural cytotoxicity inhibition. Eur J Clin Invest. 2000 Jan;30(1):58-65.
Storey A, McArdle F, Friedmann PS, Jackson MJ, Rhodes LE. Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. J Invest Dermatol. 2005 Jan;124(1):248-55.

For educational purposes only. Consult your physician for any health problems.

*These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

 

 

 

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